반응 #699238

반응 방정식

2-methyl-4-nitroaniline

ethyl (ethoxymethylene)-cyanoacetate

→

2-Cyano-3-(2-methyl-4-nitrophenyl)acrylic Acid Ethyl Ester

용매

toluene

—

ether-hexane

반응 조건

후처리

1. 1
   온도was refluxed for 24 h
2. 2
   온도cooled
3. 3
   여과filtered
4. 4
   세척The resulting white solid was washed with hexane-ether
5. 5
   기타dried
6. 6
   기타to give 63.9 g, mp 180-210° C.

실험 절차

A mixture of 2-methyl-4-nitroaniline (38.0 g, 250 mmol), ethyl (ethoxymethylene)-cyanoacetate (50.8 g, 300 mmol), and 200 ml of toluene was refluxed for 24 h, cooled, diluted with 1:1 ether-hexane, and filtered. The resulting white solid was washed with hexane-ether and dried to give 63.9 g, mp 180-210° C.

출처