반응 #698655

ord-b91f49ded366413b9e1ec08e9f999e10

반응 방정식

CC1(C)S[C@@H]2[C@H](NC(=O)Cc3ccccc3)C(=O)N2[C@H]1C(=O)[O-].[K+]
penicillin
CN[C@@H]1[C@H](O[C@H]2[C@H](O[C@H]3[C@H](O)[C@@H](O)[C@H](NC(=N)N)[C@@H](O)[C@@H]3NC(=N)N)O[C@@H](C)[C@]2(O)C=O)O[C@@H](CO)[C@H](O)[C@H]1O
streptomycin
NC(=O)CC[C@H](N)C(=O)O
glutamine
→
Nc1ccn([C@H]2C=C[C@@H](CO)O2)c(=O)n1
solutions
Nc1ccn([C@H]2C=C[C@@H](CO)O2)c(=O)n1
2'3'-dideoxy-2',3'-didehydrocytidine

반응물

—
Nucleoside
CC1(C)S[C@@H]2[C@H](NC(=O)Cc3ccccc3)C(=O)N2[C@H]1C(=O)[O-].[K+]
penicillin
CN[C@@H]1[C@H](O[C@H]2[C@H](O[C@H]3[C@H](O)[C@@H](O)[C@H](NC(=N)N)[C@@H](O)[C@@H]3NC(=N)N)O[C@@H](C)[C@]2(O)C=O)O[C@@H](CO)[C@H](O)[C@H]1O
streptomycin
NC(=O)CC[C@H](N)C(=O)O
glutamine

시약

없음

반응 조건

상세 조건
See reaction.notes.procedure_details.

후처리

  1. 1
    workup.DISTILLATIONdistilled water
  2. 2
    여과filter
  3. 3
    기타Subsequent dilutions were prepared in RPMI 1640 medium

실험 절차

Nucleoside Analogs: One millimolar solutions were prepared in glass distilled water and filter sterilized through 0.2μ filters. Subsequent dilutions were prepared in RPMI 1640 medium containing 15% fetal calf serum, penicillin, streptomycin and glutamine.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US06001818uspto-grants-1999_12