반응 #69687

반응 방정식

3-hydroxyphthalic anhydride

2,4-dimethoxybenzylamine

acetic acid

→

title compound

수율 73.0%

4-Hydroxy-2-(2,4-dimethoxy-benzyl)-isoindole-1,3-dione

수율 73.0%

용매

water

반응 조건

후처리

1. 1
   온도to cool
2. 2
   여과The white solid was collected by filtration
3. 3
   세척washed well with water
4. 4
   기타dried

실험 절차

A mixture of 3-hydroxyphthalic anhydride (1.24 g, 7.6 mmol), 2,4-dimethoxybenzylamine (1.14 mL, 7.6 mmol) and acetic acid (5 mL) was heated at 80° C. for 24 hours. The mixture was allowed to cool and diluted with water (20 mL). The white solid was collected by filtration, washed well with water and dried to give the title compound (1.73 g, 73%). 1H NMR (DMSO-d6) 11.00 (1H, s), 7.62 (1H, dd), 7.29 (1H, d), 7.21 (1H, d), 6.90 (1H, d), 6.56 (1H, d), 6.43 (1H, dd), 4.59 (2H, s), 3.79 (3H, s), 3.72 (3H, s). MS: [M−H+] 314.

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