반응 #696703

반응 방정식

4-Vinylbenzyl chloride

Ethyl acetoacetate

sodium ethoxide

→

ethyl 2-(4-vinylbenzyl)-3-oxobutanoate

수율 95.0%

용매

ethanol

반응 조건

후처리

1. 1
   온도was cooled in an ice-water bath
2. 2
   온도The mixture was refluxed for 16 hours
3. 3
   여과the resulting slurry was filtered
4. 4
   기타to remove any salt
5. 5
   기타the solution collected
6. 6
   기타The solvent was removed under reduced pressure

실험 절차

Ethyl acetoacetate (27.61 g, 0.21 mol) was dissolved in ethanol (100 ml) which was cooled in an ice-water bath, and sodium ethoxide (15.59 g, 0.22 mol) was added. 4-Vinylbenzyl chloride (33.92 g, 0.2 mole) was added. The mixture was refluxed for 16 hours, then the resulting slurry was filtered to remove any salt, and the solution collected. The solvent was removed under reduced pressure to give ethyl 2-(4-vinylbenzyl)-3-oxobutanoate in the form of a light red liquid (49 g) in 95% yield.

출처