반응 #6962

반응 방정식

3-nitro-4-fluorobenzoic acid

→

3-amino-4-fluorobenzoic acid

용매

MeOH

반응 조건

후처리

1. 1
   기타The catalyst was removed by filtration
2. 2
   세척washed with methanol
3. 3
   기타the volatiles were removed in vacuo

실험 절차

A mixture of 3-nitro-4-fluorobenzoic acid (1.85 g, 10.0 mmol) in MeOH (10 mL) and 5% Pd/C (100 mg) was stirred under an atmosphere of hydrogen and for 6 h. The catalyst was removed by filtration, washed with methanol and the volatiles were removed in vacuo to give compound 8A, 3-amino-4-fluorobenzoic acid, as a light yellow solid (1.50 g, 9.67 mmol, 97%).

출처