반응 #69405

반응 방정식

N′,1-dihydroxy-2,3-dihydro-1H-indene-4-carboximidamide

4-ethoxy-3-(trifluoromethyl)benzoic acid

HOBt

EDCI

NaCl

→

4-(5-(4-ethoxy-3-(trifluoromethyl)phenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-ol

수율 51.0%

용매

DMF

반응 조건

후처리

1. 1
   workup.STIRRINGThe reaction was stirred for additional 30 min at room temperature
2. 2
   workup.ADDITIONThe reaction was diluted
3. 3
   추출extracted with EtOAc (80 ml×3)
4. 4
   건조The organic phase was dried over Na2SO4 anhydrous
5. 5
   농축concentrated under reduced pressure
6. 6
   기타The product was purified by column chromatography

실험 절차

In a microwave vial, a stirring solution of 4-ethoxy-3-(trifluoromethyl)benzoic acid (200 mg, 0.85 mmol) in DMF was treated with HOBt (151 mg, 1.11 mmol) and EDCI (212 mg, 1.11 mmol) at room temperature. The reaction was stirred for 20 min followed by addition, in a single portion, of N′,1-dihydroxy-2,3-dihydro-1H-indene-4-carboximidamide (213 mg, 1.11 mmol). The reaction was stirred for additional 30 min at room temperature and then heated to 130° C. for 35 min in the initiator. The reaction was diluted using a saturated solution of NaCl and extracted with EtOAc (80 ml×3). The organic phase was dried over Na2SO4 anhydrous and concentrated under reduced pressure. The product was purified by column chromatography using CH2Cl2:MeOH (9:1) to offer the product as white solid in 51% yield (200 mg).

출처