반응 #69403

반응 방정식

2-bromo-1-phenylethanone

3,4-diethoxybenzamide

NaHCO3

→

product

수율 17.0%

2-(3,4-diethoxyphenyl)-4-phenyloxazole

수율 17.0%

용매

DMF

반응 조건

후처리

1. 1
   추출extracted with EtOAc (50 ml×3)
2. 2
   세척The combined organic phases were washed with a saturated solution of NaCl (30 ml×2)
3. 3
   농축concentrated under reduced pressure
4. 4
   기타The product was purified by column chromatography

실험 절차

In a microwave vial were dissolved 2-bromo-1-phenylethanone (95 mg, 0.478 mmol) and 3,4-diethoxybenzamide (100 mg, 0.478 mmol) in DMF (5 ml) and the reaction was heated at 170° C. for 40 min. The reaction mixture was poured in a saturated solution of NaHCO3 and extracted with EtOAc (50 ml×3). The combined organic phases were washed with a saturated solution of NaCl (30 ml×2) and concentrated under reduced pressure. The product was purified by column chromatography using CH2Cl2:MeOH (95:5) to yield 25 mg (17%) of the product. MS (EI) m/z: 310 (M+)

출처