반응 #691980

반응 방정식

diisopropylamine

phenyllithium cyclopentane diethyl ether

tetrahydrofuran

tetrahydrofuran

sodium thiosulfate

ammonia

ammonium chloride

hydrogen peroxide

→

title compound

2-Chloro-3,4-dimethoxypyridine

용매

ethyl acetate

acetic acid

반응 조건

후처리

1. 1
   workup.WAITat −18° C. for another 20 minutes
2. 2
   온도The reaction mixture was cooled again to −78° C.
3. 3
   workup.STIRRINGthe resulting mixture was stirred at 0° C. for 20 minutes
4. 4
   workup.STIRRINGthe mixture was stirred at room temperature for 2 hours
5. 5
   세척the mixture was washed with saturated brine
6. 6
   기타The ethyl acetate layer obtained upon filtration through silica gel
7. 7
   농축was concentrated under reduced pressure

실험 절차

A solution of diisopropylamine (84.0 μl, 0.599 mmol) and the compound of Example B240 (860 mg, 5.99 mmol) in tetrahydrofuran (4 ml) was added to a solution of 1.06 M phenyllithium cyclopentane-diethyl ether solution in tetrahydrofuran (11 ml) cooled to −78° C. under nitrogen atmosphere. This reaction mixture was stirred at −40° C. for 1 hour, then at −18° C. for another 20 minutes. The reaction mixture was cooled again to −78° C., trimethoxyborate (2.04 ml, 18.0 mmol) was added dropwise thereto, and the resulting mixture was stirred at 0° C. for 20 minutes. At that temperature, aqueous ammonia (29%, 30 ml), ammonium chloride (4.5 g,), and an aqueous hydrogen peroxide solution (30%, 12 ml) were added in this order, and the mixture was stirred at room temperature for 2 hours. Saturated sodium thiosulfate, acetic acid and ethyl acetate were added, and the mixture was washed with saturated brine. The ethyl acetate layer obtained upon filtration through silica gel was concentrated under reduced pressure. The resulting residue was treated in the same manner as in Example B231 to obtain the title compound (31.3 mg).

출처