반응 #691675

반응 방정식

(3,4-dimethoxy-phenyl)-acetic acid

EDC

ethyl-diisopropyl-amine

5-(2-ethyl-2H-tetrazol-5-yl)-4-phenyl-thiazol-2-ylamine

→

2-(3,4-Dimethoxy-phenyl)-N-[5-(2-ethyl-2H-tetrazol-5-yl)-4-phenyl-thiazol-2-yl]-acetamide

수율 13.0%

반응 조건

후처리

1. 1
   기타Purification

실험 절차

200 μL of a 0.6M stock solution of (3,4-dimethoxy-phenyl)-acetic acid was mixed with 200 μL of a 0.3M stock solution of EDC containing 1 eq. of ethyl-diisopropyl-amine. Then 100 μL of a 0.3M stock solution of 5-(2-ethyl-2H-tetrazol-5-yl)-4-phenyl-thiazol-2-ylamine containing 1 eq. of DMAP was added. The reaction mixture was shaken overnight at ambient temperature. Purification was performed by preparative LC-MS. Yield: 13%.

출처