반응 #6916

반응 방정식

7-Iodoquinazolin-4-one

phosphorous oxychloride

→

title compound

4-Chloro-7-iodoquinazoline

반응 조건

후처리

1. 1
   온도at reflux under nitrogen for 2 hours
2. 2
   온도The mixture was cooled
3. 3
   기타evaporated
4. 4
   기타partitioned between saturated aqueous sodium carbonate and ethyl acetate
5. 5
   기타The organic phase was dried
6. 6
   농축concentrated in vacuo

실험 절차

7-Iodoquinazolin-4-one (0.46 g) was treated with phosphorous oxychloride (5 ml) at reflux under nitrogen for 2 hours. The mixture was cooled, evaporated and partitioned between saturated aqueous sodium carbonate and ethyl acetate. The organic phase was dried and concentrated in vacuo to give the title compound (0.43 g); m/z (M+1+) 291.

출처