반응 #6915

반응 방정식

7-Amino-quinazolin-4-one

potassium iodide

sodium nitrite

→

title compound

수율 17.8%

7-Iodoquinazoline-4-one

수율 17.8%

용매

HCl

water

water

반응 조건

후처리

1. 1
   온도cooled in an ice bath
2. 2
   기타partitioned between ethyl acetate and sodium thiosulphate
3. 3
   기타The organic phase was dried
4. 4
   농축concentrated in vacuo

실험 절차

7-Amino-quinazolin-4-one (R. Dempsy and E. Skito, Biochemistry, 30, 1991, 8480) (1.61 g) was suspended in 6N HCl (20 ml) and cooled in an ice bath. A solution of sodium nitrite (0.75 g) in water (10 ml) was added dropwise over 15 minutes. After a further 10 minutes, a solution of potassium iodide (1.66 g) in water (5 ml) was added dropwise. The mixture was warmed to 20° C. and after 3 hours partitioned between ethyl acetate and sodium thiosulphate. The organic phase was dried and concentrated in vacuo to give the title compound (0.485 g); m/z (M+1+) 271.

출처