반응 #691384

반응 방정식

pyridine

acetyl chloride

6-Aminohexanoic acid methyl ester hydrochloride

hydrochloric acid

→

methyl 6-acetylamino-hexanoate

용매

methylene chloride

chloroform

반응 조건

후처리

1. 1
   기타the mixture is separated
2. 2
   세척the organic layer is washed with a saturated brine
3. 3
   건조dried over magnesium sulfate
4. 4
   농축concentrated under reduced pressure

실험 절차

6-Aminohexanoic acid methyl ester hydrochloride (5 g) is dissolved in methylene chloride (20 ml) and thereto are added pyridine (4.5 ml) and acetyl chloride (2 ml), and the mixture is stirred at room temperature for 1 hour and 45 minutes. To the reaction solution are added a 1N-hydrochloric acid and chloroform, and the mixture is separated, and the organic layer is washed with a saturated brine, dried over magnesium sulfate, and concentrated under reduced pressure to give methyl 6-acetylamino-hexanoate (5.19 g) as a crude product. MS (m/z): 188 [M+H]+

출처