반응 #69138

반응 방정식

5-bromo-1H-pyrrolo[2,3-b]pyridine

ammonium hydroxide

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product

수율 63.0%

1H-pyrrolo[2,3-b]pyridin-5-amine

수율 63.0%

용매

EtOAc

반응 조건

후처리

1. 1
   온도heated in a sealed tube overnight
2. 2
   여과the insoluble black solid was filtered off
3. 3
   추출The filtrate was extracted (EtOAc/Water)
4. 4
   세척the organic layer washed with saturated aqueous ammonium chloride
5. 5
   건조The organics were dried over magnesium sulphate
6. 6
   여과filtered
7. 7
   기타evaporated to dryness

실험 절차

5-bromo-1H-pyrrolo[2,3-b]pyridine (6.0 g, 30.45 mmol) in ammonium hydroxide (120 mL) was treated with copper sulphate pentahydrate (1.50 g, 6.09 mmol, 0.2 eq) and heated in a sealed tube overnight. The reaction was diluted with EtOAc and the insoluble black solid was filtered off. The filtrate was extracted (EtOAc/Water) and the organic layer washed with saturated aqueous ammonium chloride, followed by water and brine. The organics were dried over magnesium sulphate, filtered and evaporated to dryness to give the product as a pale brown solid (2.57 g, 63%)

출처