반응 #69128

반응 방정식

(R)-tert-butyl 1-(4-hydroxyphenyl)ethylcarbamate

→

title compound

수율 61.0%

(R)-tert-butyl 1-(4-hydroxycyclohexyl)ethylcarbamate

수율 61.0%

용매

methanol

반응 조건

후처리

1. 1
   여과The rhodium catalyst was filtered off
2. 2
   농축the mother liquors were concentrated in vacuo
3. 3
   기타The residue was purified on silica gel by flash column chromatography

실험 절차

(R)-tert-butyl 1-(4-hydroxyphenyl)ethylcarbamate (described in the literature: WO 2007035154 (A1)) (100 mg, 0.4214 mmol) was dissolved in methanol (5 mL). A methanolic (5 mL) solution of rhodium on alumina (10 Wt %, 10 mg) was added. The reaction mixture was place under a hydrogen atmosphere and stir at room temperature for 18 hours. The rhodium catalyst was filtered off and the mother liquors were concentrated in vacuo. The residue was purified on silica gel by flash column chromatography to afford the title compound (62 mg, 61% yield).

출처