반응 #6910

반응 방정식

product

N-[1-(6-cyanoquinolin-2-yl)pyrrolidin-3-yl]-2,2-dimethylpropanamide

hydroxyl amine hydrochloride

sodium carbonate

→

N-(1-{6-[(Hydroxyamino)(imino)methyl]quinolin-2-yl}pyrrolidin-3-yl)-2,2-dimethylpropanamide

용매

dichloromethane

water

ethanol

반응 조건

후처리

1. 1
   세척washed twice with brine
2. 2
   건조dried over sodium sulfate
3. 3
   여과filtered through a fritted funnel
4. 4
   기타the volatiles were removed under vacuum
5. 5
   기타This provided the product, MS
6. 6
   기타m/z 356, which was used in the next step without further purification

실험 절차

A mixture of the product of Step D (60 mg; 0.1863 mmol), hydroxyl amine hydrochloride (3 eq.), sodium carbonate (4 eq.) in 1.5 mL water and 2.5 mL ethanol was heated to 90° C. for 6 h. The mixture was diluted with dichloromethane, washed twice with brine, dried over sodium sulfate, filtered through a fritted funnel and the volatiles were removed under vacuum. This provided the product, MS: m/z 356, which was used in the next step without further purification.

출처