반응 #69075

반응 방정식

3-Chloropropanol

quinolin-4-ol

potassium carbonate

potassium iodide

→

solid

수율 28.0%

3-(quinolin-4-yloxy)propan-1-ol

수율 28.0%

용매

DMF

반응 조건

후처리

1. 1
   workup.STIRRINGthe reaction was stirred until the starting material
2. 2
   기타was consumed
3. 3
   workup.ADDITIONThe reaction was diluted with dichloromethane
4. 4
   추출extracted with water

실험 절차

A suspension of quinolin-4-ol (1.35 g, 9.30 mmol), anhydrous potassium carbonate (3.73 g, 26 mmol) and potassium iodide (4.23 g) in anhydrous DMF (8 mL) was stirred at 25° C. for 30 minutes. 3-Chloropropanol (2.93 g, 31 mmol) was added and the reaction was stirred until the starting material was consumed. The reaction was diluted with dichloromethane and extracted with water. The product was obtained as a slightly yellow solid (0.5298 g, 28%) after evaporation of the dichloromethane layer, and was used for the next step without further purification. 1H NMR (400 MHz, CDCl3): 2.09 (2H, m), 3.93 (2H, t, J=5.6 Hz), 4.10 (2H, t, J=5.6 Hz), 4.51 (11H, s), 6.25 (1H, d, J=5.5 Hz), 7.32 (1H, t, J=7.4 Hz), 7.56 (1H, t, J=8.2 Hz), 7.90 (1H, d, J=8.4 Hz), 7.93 (1H, d, J=8.4 Hz), 8.36 (1H, d, J=5.3 Hz).

출처