반응 #6907

반응 방정식

2-iodoaniline

dimethylmaleate

triethylamine

→

methyl 2-oxo-1,2-dihydroquinoline-4-carboxylate

용매

acetonitrile

반응 조건

후처리

1. 1
   기타The tube was flushed with nitrogen
2. 2
   기타sealed
3. 3
   온도The sealed tube was heated at 100° for 3.5 h
4. 4
   여과the resulting solids filtered
5. 5
   세척washed with acetonitrile
6. 6
   workup.DISSOLUTIONThe solids were dissolved in chloroform
7. 7
   기타the solvent removed under vacuum
8. 8
   기타to provide a solid

실험 절차

In a heavy-walled PYREX tube was placed 2-iodoaniline (2.84 g, 13 mmol), dimethylmaleate (2.44 g, 17 mmol), triethylamine (1.4 mL, 10 mmol), palladium diacetate (31 mg, 0.14 mmol) and 6 mL acetonitrile. The tube was flushed with nitrogen and sealed. The sealed tube was heated at 100° for 3.5 h then cooled to r.t. The tube was opened and the resulting solids filtered and washed with acetonitrile. The solids were dissolved in chloroform and the solvent removed under vacuum to provide a solid.

출처