반응 #68957

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5-(8-bromoisoquinolin-3-ylamino)pyrazine-2-carbonitrile

N-(2-aminoethyl)morpholine

→

title compound

5-(8-(2-morpholinoethylamino)isoquinolin-3-ylamino)pyrazine-2-carbonitrile

반응 조건

후처리

1. 1
   기타those described in Synthesis 5-1
2. 2
   기타the reaction at 140° C.

실험 절차

The title compound was prepared using methods analogous to those described in Synthesis 5-1, replacing 3,8-dichloroisoquinoline with 5-(8-bromoisoquinolin-3-ylamino)pyrazine-2-carbonitrile and replacing (R)-5-amino-3-(pyrrolidin-3-yloxy)pyrazine-2-carbonitrile with N-(2-aminoethyl)morpholine, and conducting the reaction at 140° C.

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