반응 #68950

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5-(1-(4-Methoxybenzyl)-1H-imidazo[4,5-c]pyridin-6-ylamino)pyrazine-2-carbo-nitrile

trifluoroacetic acid

→

title compound

수율 8.0%

5-(1H-imidazo[4,5-c]pyridin-6-ylamino)pyrazine-2-carboxamide

수율 8.0%

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후처리

1. 1
   기타The solution was evaporated to dryness
2. 2
   기타the residue was purified

실험 절차

5-(1-(4-Methoxybenzyl)-1H-imidazo[4,5-c]pyridin-6-ylamino)pyrazine-2-carbo-nitrile (0.16 mmol) was treated overnight with trifluoroacetic acid at 80° C. The solution was evaporated to dryness and the residue was purified using preparative HPLC to give the title compound (3.23 mg, 8%). 1H NMR (d6-DMSO, 400 MHz) δ 12.68 (br s, 1H), 10.46 (br s, 1H), 8.76 (d, 1H, J=1.2 Hz), 8.72 (d, 2H, =1.2 Hz), 8.28 (br s, 2H), 7.90 (s, 1H), 7.51 (s, 1H). LCMS (2) Rt=1.02 min; m/z (ESI+) 256 (MH+), (ESI−) 254 (M−H).

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