반응 #68949

반응 방정식

5-(1-(4-Methoxybenzyl)-1H-imidazo[4,5-c]pyridin-6-ylamino)pyrazine-2-carbonitrile

TFA

→

title compound

수율 100.0%

5-(1H-imidazo[4,5-c]pyridin-6-ylamino)pyrazine-2-carbonitrile

수율 100.0%

반응 조건

후처리

1. 1
   세척Isolation by SPE on a MP-TsOH cartridge, eluting with 2N ammonia in methanol
2. 2
   농축followed by concentration

실험 절차

5-(1-(4-Methoxybenzyl)-1H-imidazo[4,5-c]pyridin-6-ylamino)pyrazine-2-carbonitrile (10.6 mg, 30 μmol) was treated with TFA at 80° C. over 30 minutes. Isolation by SPE on a MP-TsOH cartridge, eluting with 2N ammonia in methanol, followed by concentration, gave the title compound as a white solid (7.02 mg, 100%). 1H NMR (d6-DMSO, 400 MHz) δ 12.79 (br s, 1H), 10.85 (br s, 1H), 8.76 (s, 2H), 8.75 (s, 1H), 8.35 (s, 1H), 8.26 (s, 1H). LCMS (2) Rt=1.36 min; m/z (ESI+) 238 (MH+), (ESI−) 236 (M−H).

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