반응 #689439

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3-nitro[1,5]naphthyridin-4-amine

[1,5]naphthyridine-3,4-diamine

triethyl orthoacetate

quinoline-3,4-diamine

3-nitroquinolin-4-amine

→

2-methyl-1H-imidazo[4,5-c]quinoline

2-methyl-1H-imidazo[4,5-c][1,5]naphthyridine

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실험 절차

In steps (2) and (3) of Reaction Scheme IX, a 3-nitroquinolin-4-amine or 3-nitro[1,5]naphthyridin-4-amine of Formula LXIX is first reduced to a quinoline-3,4-diamine or [1,5]naphthyridine-3,4-diamine of Formula LXX, which is then treated with a carboxylic acid equivalent, such as triethyl orthoacetate, to provide a 2-methyl-1H-imidazo[4,5-c]quinoline or 2-methyl-1H-imidazo[4,5-c][1,5]naphthyridine of Formula LXXI. Steps (2) and (3) of Reaction Scheme IX can be carried out according to the methods described in steps (2) and (3) of Reaction Scheme I.

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