반응 #68928

반응 방정식

5-Oxiranylmethoxy-quinoline

7-naphthalen-2-yl-7,9-diaza-bicyclo[4.2.2]dec-3-ene

DIPEA

→

title compound

1-(9-Naphthalen-2-yl-7,9-diaza-bicyclo[4.2.2]dec-3-en-7-yl)-3-(quinolin-5-yloxy)-propan-2-ol

용매

ethanol

반응 조건

후처리

1. 1
   기타The solvent was evaporated in vacuo
2. 2
   기타to yield a crude solid
3. 3
   기타that was purified with flash chromatography gradient [30% EtOAc/heptane to 100% EtOAc]

실험 절차

5-Oxiranylmethoxy-quinoline (13 mg, 0.065 mmol), 7-naphthalen-2-yl-7,9-diaza-bicyclo[4.2.2]dec-3-ene (20 mg, 0.042 mmol), DIPEA (0.1 mL, 0.55 mmol) and ethanol (2 mL) were μW for 900 sec at 130° C. in a μW reaction tube. The solvent was evaporated in vacuo to yield a crude solid that was purified with flash chromatography gradient [30% EtOAc/heptane to 100% EtOAc] to yield the title compound as its free base, as a residue.

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