반응 #68927

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2-Methyl-4-oxiranylmethoxy-1H-indole

7-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-7,9-diaza-bicyclo[4.2.2]dec-3-ene

chloroform

→

title compound

1-[9-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-7,9-diaza-bicyclo[4.2.2]dec-3-en-7-yl]-3-(2-methyl-1H-indol-4-yloxy)-propan-2-ol

용매

ethanol

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후처리

1. 1
   기타at 130° C.
2. 2
   기타The solvent was evaporated under reduced pressure
3. 3
   기타to yield a crude solid
4. 4
   기타that was purified with flash chromatography gradient [20% Ethyl acetate/heptane to 100% Ethyl acetate]

실험 절차

2-Methyl-4-oxiranylmethoxy-1H-indole (25 mg, 0.123 mmol), 7-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-7,9-diaza-bicyclo[4.2.2]dec-3-ene (34 mg, 0.125 mmol), chloroform (1 mL), ethanol (3 mL) were heated for 900 sec. at 130° C. in a μW reaction tube. The solvent was evaporated under reduced pressure to yield a crude solid that was purified with flash chromatography gradient [20% Ethyl acetate/heptane to 100% Ethyl acetate] to yield the title compound as a residue.

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