반응 #68918

반응 방정식

Z-(1S,6S)-7-naphthalen-2-ylmethyl-7,9-diaza-bicyclo[4.2.2]dec-3-ene

ethyl acetate

4-oxiranylmethoxy-1H-indole

→

title compound

1-(1H-Indol-4-yloxy)-3-(9-naphthalen-2-ylmethyl-7,9-diaza-bicyclo[4.2.2]dec-3-en-7-yl)-propan-2-ol

용매

ethanol

반응 조건

후처리

1. 1
   기타The solvent was evaporated
2. 2
   기타to yield a crude oil, which
3. 3
   기타was purified via flash chromatography (15% Ethyl acetate/heptane to 100% Ethyl acetate)

실험 절차

Z-(1S,6S)-7-naphthalen-2-ylmethyl-7,9-diaza-bicyclo[4.2.2]dec-3-ene (30 mg, 0.064 mmol), ethyl acetate (0.5 mL) and 4-oxiranylmethoxy-1H-indole (50 mg, 0.26 mmol) were placed in a μW tube with ethanol (3 ml) and heated to 95° C. for 900 sec. The solvent was evaporated to yield a crude oil, which was purified via flash chromatography (15% Ethyl acetate/heptane to 100% Ethyl acetate) to yield the title compound as a residue.

출처