반응 #689173

반응 방정식

N-cyclohexylmethyl-4-(2-propynyloxy)-3,5-dimethoxybenzamide

Lawesson's Reagent

→

N-cyclohexylmethyl-4-(2-propynyloxy)-3,5-dimethoxybenzenethioamide

수율 63.6%

용매

toluene

반응 조건

후처리

1. 1
   기타the mixture obtained
2. 2
   온도was heated
3. 3
   온도under reflux for 2 hours
4. 4
   농축Then, the reaction mixture was concentrated

실험 절차

To 30 ml of toluene were added 1.2 g of N-cyclohexylmethyl-4-(2-propynyloxy)-3,5-dimethoxybenzamide and 1.8 g of Lawesson's Reagent and the mixture obtained was heated under reflux for 2 hours. Then, the reaction mixture was concentrated. The residue was subjected to silica gel column chromatography to obtain 0.80 g of N-cyclohexylmethyl-4-(2-propynyloxy)-3,5-dimethoxybenzenethioamide (hereinafter, described as the compound 33 of the present invention) represented by the formula:

출처