반응 #6891

반응 방정식

product

2-chloro-6-nitroquinoline

piperidine

→

product

6-nitro-2-piperidin-1-ylquinoline

용매

ethanol

반응 조건

후처리

1. 1
   온도heated
2. 2
   온도at reflux for 4 h
3. 3
   기타the solvent removed under vacuum
4. 4
   기타The mixture was transferred to a separatory funnel
5. 5
   세척washed with water (3×15 mL)
6. 6
   건조The organic layer was dried over sodium sulfate
7. 7
   여과filtered
8. 8
   기타the solvent removed under vacuum

실험 절차

The product (208 mg, 1.0 mmol) from Step B and piperidine (0.5 mL, 5 mmol) were mixed in absolute ethanol (3 mL) and then heated at reflux for 4 h. The reaction mixture was cooled to r.t., and the solvent removed under vacuum. The solids were taken up in EtOAc (125 mL). The mixture was transferred to a separatory funnel and washed with water (3×15 mL). The organic layer was dried over sodium sulfate, filtered and the solvent removed under vacuum to afford the product as a yellow solid, MS: m/z 258 (MH+) which was used without further purification.

출처