반응 #6887

반응 방정식

propargyl bromide

4-methylpiperidine

potassium carbonate

→

oil

수율 92.0%

4-methyl-1-(2-propynyl)piperidine

수율 92.0%

용매

acetone

반응 조건

후처리

1. 1
   여과filtered
2. 2
   농축The filtrate was concentrated under reduced pressure
3. 3
   세척The organic phase was washed with water (3×15 ml)
4. 4
   건조dried with sodium sulfate
5. 5
   농축concentrated under reduced pressure
6. 6
   workup.DISTILLATIONDistillation of the residue under reduced pressure

실험 절차

At 0–5° C., propargyl bromide (12.01 g) was added dropwise with stirring to a suspension of 4-methylpiperidine (10.0 g) and potassium carbonate (13.96 g) in dry acetone (80 ml). The mixture was stirred at 50° C. for 6 hours and then filtered. The filtrate was concentrated under reduced pressure and the residue was taken up in dichloromethane. The organic phase was washed with water (3×15 ml), dried with sodium sulfate and concentrated under reduced pressure. Distillation of the residue under reduced pressure gave 12.73 g of an oil of boiling point 60° C./16 mm Hg.

출처