반응 #68779

반응 방정식

(S)—N-(1-{4-[3-(4-Benzyloxy-phenoxy)-azetidin-1-yl]-phenyl}-ethyl)-acetamide

→

desired product

(S)—N-(1-{4-[3-(4-Hydroxy-phenoxy)-azetidin-1-yl]-phenyl}-ethyl)-acetamide

용매

MeOH

반응 조건

후처리

1. 1
   여과The mixture is filtered
2. 2
   농축concentrated in vacuo

실험 절차

1.3 g (3.12 mmol) (S)—N-(1-{4-[3-(4-Benzyloxy-phenoxy)-azetidin-1-yl]-phenyl}-ethyl)-acetamide (Ex. 8.5) and 130 mg Pd/C (10%) in 50 mL MeOH are hydrogenated at 3 bar and 50° C. for 12 h. The mixture is filtered and concentrated in vacuo. The residue is titurated with diisopropyl ether to yield the desired product.

출처