반응 #68763

ord-a7437a70bed24e358008440ab46f21fe

반응 방정식

CC1(C)C(=O)Nc2ccc(C(F)(F)F)cc21
3,3-dimethyl-5-trifluoromethyl-1,3-dihydroindol-2-one
CC(C)(C)C(=O)OCCl
chloromethyl pivalate
CC#CC(CC(=O)OC)c1ccc(O)cc1
methyl 3-(4-hydroxyphenyl)hex-4-ynoate
→
CC#CC(CC(=O)O)c1ccc(OCN2C(=O)C(C)(C)c3cc(C(F)(F)F)ccc32)cc1
3-[4-(3,3-dimethyl-2-oxo-5-trifluoromethyl-2,3-dihydroindol-1-ylmethoxy)phenyl]hex-4-ynoic acid

반응물

CC1(C)C(=O)Nc2ccc(C(F)(F)F)cc21
3,3-dimethyl-5-trifluoromethyl-1,3-dihydroindol-2-one
CC(C)(C)C(=O)OCCl
chloromethyl pivalate
CC#CC(CC(=O)OC)c1ccc(O)cc1
methyl 3-(4-hydroxyphenyl)hex-4-ynoate

시약

없음

반응 조건

상세 조건
See reaction.notes.procedure_details.

실험 절차

Analogously to example 1, 3,3-dimethyl-5-trifluoromethyl-1,3-dihydroindol-2-one, chloromethyl pivalate and methyl 3-(4-hydroxyphenyl)hex-4-ynoate were used to obtain 3-[4-(3,3-dimethyl-2-oxo-5-trifluoromethyl-2,3-dihydroindol-1-ylmethoxy)phenyl]hex-4-ynoic acid.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US08530413B2uspto-grants-2013_09