반응 #68747
ord-6f7641894d3b4895a473f13086f5e497
반응 방정식
반응 조건
상세 조건
See reaction.notes.procedure_details.
후처리
- 1추출the crude product is extracted with ethyl acetate (3×15 ml)
- 2세척washed with brine (10 ml)
- 3건조dried over anhydrous magnesium sulfate
- 4여과filtered
- 5기타the filtrate is evaporated to dryness under reduced pressure
실험 절차
A solution of 2-(4′-chloro-4-ethylbiphen-3-yl)-3-methoxycyclopent-2-enone (200 mg, 0.61 mmol) in acetone (4 ml) and 2M aqueous hydrochloric acid (4 ml) is heated at 120° C. for 20 minutes under microwave irradiation. The reaction mixture is diluted with water (20 ml) and 2M aqueous hydrochloric acid (10 ml), and the crude product is extracted with ethyl acetate (3×15 ml). The organic extracts are combined, washed with brine (10 ml), dried over anhydrous magnesium sulfate, filtered and the filtrate is evaporated to dryness under reduced pressure to give 2-(4′-chloro-4-ethylbiphen-3-yl)-1,3-cyclopentanedione.