반응 #68664

반응 방정식

3-chloro-6-(3-methylisothiazol-5-yl)pyridazine

hydrazine

→

1-(6-(3-methylisothiazol-5-yl)pyridazin-3-yl)hydrazine

용매

water

sec-BuOH

반응 조건

후처리

1. 1
   온도The mixture was cooled to 23° C.
2. 2
   여과The solid was collected by filtration
3. 3
   세척was washed by 2 mL of water
4. 4
   기타to produce a yellow solid

실험 절차

A mixture of 3-chloro-6-(3-methylisothiazol-5-yl)pyridazine (0.85 g, 4.0 mmol) and anhydrous hydrazine (3.8 ml, 120 mmol) in 30 mL of sec-BuOH was heated at 130° C. for 3 hours. The mixture was cooled to 23° C. and diluted with 5 mL of water. The solid was collected by filtration and was washed by 2 mL of water to produce a yellow solid. MS (ESI pos. ion) m/z: 208 (MH+). Calc'd exact mass for C8H6ClN3S: 207.

출처