반응 #68612

반응 방정식

4-bromo-1H-pyrazole

2,2,2-trifluoroethyl trifluoromethanesulfonate

cesium carbonate

1,4-dioxane

→

4-bromo-1-(2,2,2-trifluoroethyl)-1H-pyrazole

수율 77.1%

반응 조건

후처리

1. 1
   기타capped
2. 2
   여과The reaction mixture was filtered
3. 3
   세척the solid washed with dioxane
4. 4
   농축the filtrate was then concentrated

실험 절차

A 250 mL RB flask was charged with 4-bromo-1H-pyrazole (2.00 g, 13.6 mmol), 2,2,2-trifluoroethyl trifluoromethanesulfonate (2.35 ml, 17.0 mmol), cesium carbonate (8.87 g, 27.2 mmol), and 1,4-dioxane (40.0 ml, 468 mmol), capped, and stirred at room temperature for 20 hours. The reaction mixture was filtered and the solid washed with dioxane; the filtrate was then concentrated to give 4-bromo-1-(2,2,2-trifluoroethyl)-1H-pyrazole (2.402 g, 77.1% yield) as a crude oil.

출처