반응 #68558

반응 방정식

4-bromo-2-chlorobenzaldehyde

(r)-(+)-2-methyl-2-propanesulfinamide

→

(R,Z)—N-(4-bromo-2-chlorobenzylidene)-2-methylpropane-2-sulfinamide

용매

DCM

반응 조건

후처리

1. 1
   기타Reaction
2. 2
   여과filtered through Celite, and solid
3. 3
   세척washed repeatedly with DCM
4. 4
   농축Filtrate concentrated
5. 5
   기타then purified on silica (80 g)
6. 6
   세척eluting product with 0>30% of EtOAc/Hex

실험 절차

A suspension of 4-bromo-2-chlorobenzaldehyde (1150 mg, 5240 μmol), (r)-(+)-2-methyl-2-propanesulfinamide (1588 mg, 13100 μmol), copper(ii) sulfate (696.4 μl, 15720 μmol) in DCM (10 mL) was stirred at 37° C. for 78 h. Reaction filtered through Celite, and solid washed repeatedly with DCM. Filtrate concentrated then purified on silica (80 g) eluting product with 0>30% of EtOAc/Hex. MS (ESI pos. ion) m/z: 322/324 (MH+). Calc'd exact mass for C11H13BrClNOS: 321/323.

출처