반응 #685036

반응 방정식

sodium bicarbonate

sulfuryl chloride

4′-chloro-2′-fluoroacetophenone

methanol

→

2-Chloro-1-(4-chloro-2-fluorophenyl)ethanone

용매

heptane

heptane

반응 조건

후처리

1. 1
   기타In a 1 L round bottom flask combine
2. 2
   workup.ADDITIONAdd
3. 3
   기타drop-wise to the reaction over 60 min
4. 4
   workup.ADDITIONthen add to the reaction drop-wise
5. 5
   여과filter the biphasic suspension
6. 6
   기타to collect the title compound (38.18 g, 80%) as white needles

실험 절차

In a 1 L round bottom flask combine 4′-chloro-2′-fluoroacetophenone (40 g, 231.8 mmol), heptane (120 mL), and methanol (16 mL). Cool to 0° C. and place under nitrogen. Dissolve sulfuryl chloride (21.5 mL, 1.15 equiv.) in heptane (120 mL) and charge to an addition funnel Add drop-wise to the reaction over 60 min. Stir for 2.5 h at 0° C.; a white precipitate forms during this time. Charge the addition funnel with 1 M sodium bicarbonate (400 mL) then add to the reaction drop-wise. After all gas evolution stops, filter the biphasic suspension to collect the title compound (38.18 g, 80%) as white needles. 1H NMR (DMSO-d6) δ 5.00 (d, 2H, J=2.5 Hz), 7.43 (m, 1H), 7.63 (m, 1H), 7.89 (t, 1H, J=8.4 Hz).

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