반응 #685030

반응 방정식

NaOH

(Z)-3-((3-(3-ethoxy-3-oxopropyl)-4-oxo-4,5,6,7-tetrahydro-1 H-indol-2-yl)methylene)indolin-2-one

HCl

→

desired product

(Z)-3-((3-carboxyethyl-4-oxo-4,5,6,7-tetrahydro-1 H-indol-2-yl)methylene)indolin-2-one

용매

EtOH

반응 조건

후처리

1. 1
   온도The reaction was heated
2. 2
   온도at reflux for 2.0 h
3. 3
   여과The resultant precipitate was filtered
4. 4
   세척washed with MeOH

실험 절차

To an EtOH solution (3.0 mL) containing (Z)-3-((3-(3-ethoxy-3-oxopropyl)-4-oxo-4,5,6,7-tetrahydro-1 H-indol-2-yl)methylene)indolin-2-one (0.50 mmol) was added 3.0 N aqueous NaOH (1.0 mL). The reaction was heated at reflux for 2.0 h and cooled to room temperature. The solution was acidified with 6 N HCl to pH 3.0. The resultant precipitate was filtered and washed with MeOH to provide the desired product. 1 H NMR (DMSO-d6) δ 13.76 (s, 1 H), 11.01 (s, 1 H), 7.77 (s, 1 H), 7.76 (d, 1 H), 7.17 (dd, 1 H), 7.01 (dd, 1 H), 6.89 (dd, 1 H), 3.15 (t, 2 H), 2.91 (t, 2H), 2.36-2.41 (m, 2 H), 2.06 (t, 2 H).

출처