반응 #685026

반응 방정식

5-aminolevulinic acid hydrochloride

1,3-cyclohexanedione

sodium acetate

→

3-carboxyethyl-4-oxo-4,5,6,7-tetrahydro-1H-indole

수율 82.2%

3-Carboxyethyl-4-oxo-4,5,6,7-tetrahydro-1H-indole

수율 82.2%

용매

H2O

반응 조건

후처리

1. 1
   온도The solution was cooled to room temperature
2. 2
   여과the resultant precipitate was filtered
3. 3
   세척washed with water (200 mL×2)
4. 4
   기타air-dried

실험 절차

A mixture of 5-aminolevulinic acid hydrochloride (2, 50.0 g, 0.298 mol), 1,3-cyclohexanedione (1, 40.2 g, 0.359 mol), and sodium acetate (48.8 g, 0.595 mol) was added with H2O (125 mL). The reaction mixture was heated at 100° C. for 16 h. The solution was cooled to room temperature and the resultant precipitate was filtered, washed with water (200 mL×2), and air-dried to give 3-carboxyethyl-4-oxo-4,5,6,7-tetrahydro-1H-indole (3, 50.5 g, 0.245 mol) as yellow solids in 82% yield.

출처