반응 #685014

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N,N-dimethylsulfamoyl chloride

1,4-dioxa-8-azaspiro[4,5]decane

triethylamine

→

title compound

수율 100.0%

N,N-Dimethyl-1,4-dioxa-8-azaspiro[4.5]decane-8-sulfonamide

수율 100.0%

용매

THF

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후처리

1. 1
   기타The solids were removed by filtration
2. 2
   농축the solution was concentrated

실험 절차

To a solution of 1,4-dioxa-8-azaspiro[4,5]decane (5.0 g, 35 mmol) in THF (25 mL) was added triethylamine (5 mL, 36 mmol) followed by N,N-dimethylsulfamoyl chloride (3.7 mL, 35 mmol). The resulting white mixture was stirred at room temperature for 1 h. The solids were removed by filtration and the solution was concentrated to give the title compound as a white solid (8.7 g, 100% yield). 1H NMR (300 MHz, CDCl3) δ: 3.93 (4H, s), 3.35 (4H, t, J=5.8 Hz), 2.78 (6H, s), 1.73 (4H, t, J=5.8 Hz). LCMS (M+H) calcd for C9H19N2O4S: 251.10; found: 251.24.

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