반응 #684992

반응 방정식

1-(3-(2-(1-benzothiophene-5-yl)ethoxy)propyl)-3-azetidinol

maleic acid

→

achromatic crystal

수율 88.4%

1-(3-(2-(1-benzothiophene-5-yl)ethoxy)propyl)-3-azetidinol maleate

수율 88.4%

용매

acetone

반응 조건

후처리

1. 1
   온도The reaction mixture was gradually cooled
2. 2
   기타Thereafter, precipitated crystals
3. 3
   여과were collected by filtration

실험 절차

8.00 g of 1-(3-(2-(1-benzothiophene-5-yl)ethoxy)propyl)-3-azetidinol was dissolved in 56 ml of acetone. Thereafter, 3.19 g of maleic acid was added thereto, and the obtained mixture was heated to 60° C. for dissolution. The reaction mixture was gradually cooled, and it was then stirred at 5° C. for 30 minutes. Thereafter, precipitated crystals were collected by filtration, so as to obtain 9.89 g of an achromatic crystal, 1-(3-(2-(1-benzothiophene-5-yl)ethoxy)propyl)-3-azetidinol maleate.

출처