반응 #684984

반응 방정식

5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4,5-dihydro-pyrazole-3-carboxylic acid

ethanol

p-toluenesulfonic acid monohydrate

→

title compound

5-(4-Chloro-phenyl)-1-(2,4-dichloro-phenyl)-4,5-dihydro-1H-pyrazol-3-carboxylic acid ethyl ester

용매

toluene

반응 조건

후처리

1. 1
   온도After cooling to room temperature
2. 2
   세척the reaction mixture washed with sodium hydrogen carbonate solution and water
3. 3
   건조dried over sodium sulphate
4. 4
   기타evaporated to dryness

실험 절차

5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4,5-dihydro-pyrazole-3-carboxylic acid (0.55 g, 1.50 mmol) was dissolved in 20 mL of toluene and (2 mL) ethanol and (0.05 g) of p-toluenesulfonic acid monohydrate were added. The mixture was heated at 80° C. for 72 hours. After cooling to room temperature, the reaction mixture washed with sodium hydrogen carbonate solution and water, dried over sodium sulphate and evaporated to dryness to give the title compound in form of oil.

출처