반응 #684981

반응 방정식

Trifluoroacetic acid

(4-(dodecanoylsulfamoyl)benzyl)carbamic acid tert-butyl ester

→

trifluoroacetic salt

수율 128.9%

4-Aminomethyl-N-(dodecanoyl)benzenesulfonamide

수율 128.9%

용매

dichloromethane

반응 조건

후처리

1. 1
   기타was at room temperature
2. 2
   기타The solvents were removed in vacuo
3. 3
   workup.DISSOLUTIONThe residue was dissolved in dichloromethane (40 ml)
4. 4
   기타the solvent was removed in vacuo

실험 절차

Trifluoroacetic acid (25 ml) was at room temperature added to a solution of (4-(dodecanoylsulfamoyl)benzyl)carbamic acid tert-butyl ester (170 mg, 0.40 mmol) in dichloromethane (25 ml). The reaction mixture was stirred for 1 h at room temperature. The solvents were removed in vacuo. The residue was dissolved in dichloromethane (40 ml) and the solvent was removed in vacuo. The latter procedure was repeated once to give 0.19 g of the trifluoroacetic salt of 4-aminomethyl-N-(dodecanoyl)benzenesulfonamide.

출처