반응 #684975

반응 방정식

ethyl acetate

Potassium carbonate

methyl iodide

compound

2-(4-Bromo-2-fluorobenzyl)-3-pyridinol

→

title compound

수율 84.4%

2-(4-Bromo-2-fluorobenzyl)-3-methoxypyridine

수율 84.4%

용매

dimethylformamide

반응 조건

후처리

1. 1
   세척the reaction mixture was washed with saturated brine
2. 2
   농축concentrated under reduced pressure
3. 3
   기타The residue was purified by silica gel column chromatography

실험 절차

Potassium carbonate (38.7 mg, 0.280 mmol) and methyl iodide (10.5 μl, 0.168 mmol) were added to a solution of the compound of Example B245 (15.8 mg, 0.0560 mmol) in dimethylformamide (1 ml), and this reaction mixture was stirred at room temperature for 2 hours. After ethyl acetate was added, the reaction mixture was washed with saturated brine and concentrated under reduced pressure. The residue was purified by silica gel column chromatography to give the title compound (14.0 mg).

출처