반응 #684974

반응 방정식

ethyl acetate

Trifluoroacetic acid

compound

2-(4-Bromo-2-fluorobenzyl)-3-(methoxymethoxy)pyridine

sodium hydrogencarbonate

→

title compound

수율 84.1%

2-(4-Bromo-2-fluorobenzyl)-3-pyridinol

수율 84.1%

용매

methylene chloride

반응 조건

후처리

1. 1
   workup.ADDITIONwas added
2. 2
   세척The ethyl acetate layer was washed with saturated brine
3. 3
   농축concentrated under reduced pressure
4. 4
   기타The residue was purified by silica gel column chromatography

실험 절차

Trifluoroacetic acid (1 ml) was added to the compound of Example B244 (134 mg, 0.411 mmol) in methylene chloride (4 ml), and this reaction mixture was stirred at room temperature overnight. After neutralizing the mixture with saturated aqueous sodium hydrogencarbonate, ethyl acetate was added. The ethyl acetate layer was washed with saturated brine and concentrated under reduced pressure. The residue was purified by silica gel column chromatography to give the title compound (97.5 mg).

출처