반응 #684971

반응 방정식

Trifluoroacetic acid

compound

2-(4-Butylbenzyl)-3-(methoxymethoxy)pyridine

sodium hydrogencarbonate

ethyl acetate

→

title compound

수율 88.8%

2-(4-Butylbenzyl)-3-pyridinol

수율 88.8%

용매

methylene chloride

반응 조건

후처리

1. 1
   세척the reaction mixture was washed with saturated brine
2. 2
   농축concentrated under reduced pressure
3. 3
   기타The residue was purified by silica gel column chromatography

실험 절차

Trifluoroacetic acid (1 ml) was added to a solution of the compound of Example B229 (256 mg, 0.849 mmol) in methylene chloride (5 ml), and this reaction mixture was stirred at room temperature overnight. After a saturated aqueous sodium hydrogencarbonate solution and ethyl acetate were added, the reaction mixture was washed with saturated brine and concentrated under reduced pressure. The residue was purified by silica gel column chromatography to give the title compound (182 mg).

출처