반응 #684970

반응 방정식

Potassium carbonate

methyl iodide

compound

1-(4-Bromo-2-hydroxyphenyl)-1-butanone

→

title compound

수율 67.7%

1-(4-Bromo-2-methoxyphenyl)-1-butanone

수율 67.7%

용매

acetone

반응 조건

후처리

1. 1
   온도while heating
2. 2
   온도under reflux for 4 hours
3. 3
   여과The reaction mixture was filtered through celite, ether
4. 4
   workup.ADDITIONwas added
5. 5
   기타to remove insoluble material
6. 6
   여과by filtration
7. 7
   농축the filtrate was concentrated under reduced pressure
8. 8
   기타The residue was purified by silica gel column chromatography

실험 절차

Potassium carbonate (9.07 g) and methyl iodide (3.92 ml) were added to a solution of the compound of Example B220 (13.30 g) in acetone (75 ml), and this reaction mixture was stirred while heating under reflux for 4 hours. The reaction mixture was filtered through celite, ether was added to remove insoluble material by filtration, and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography to give the title compound (9.52 g).

출처