반응 #684966

반응 방정식

compound

1-(4-Butylbenzyl)-7-(1-ethynyl)isoquinoline

→

title compound

수율 10.4%

1-(4-Butylbenzyl)-7-ethylisoquinoline

수율 10.4%

용매

tetrahydrofuran

반응 조건

후처리

1. 1
   기타The catalyst was removed by filtration
2. 2
   농축the filtrate was concentrated
3. 3
   기타The residue was purified by silica gel column chromatography

실험 절차

Palladium-carbon (10%, 5.0 mg) was added to a solution of the compound of Example B158 (2.0 mg) in tetrahydrofuran (2.0 ml), and the mixture was stirred at room temperature under nitrogen atmosphere (1 atm) for 1 hour. The catalyst was removed by filtration, and the filtrate was concentrated. The residue was purified by silica gel column chromatography to give the title compound (0.21 mg).

출처