반응 #684965

반응 방정식

hydrobromic acid

compound

1-(4-Butylbenzyl)-6-methoxyisoquinoline

→

title compound

수율 94.6%

1-(4-Butylbenzyl)-6-isoquinolinol

수율 94.6%

반응 조건

후처리

1. 1
   온도under reflux for 19 hours
2. 2
   농축The mixture was concentrated under reduced pressure, water
3. 3
   workup.ADDITIONwas added
4. 4
   기타to precipitate crystals
5. 5
   여과The obtained crystals were collected by filtration
6. 6
   세척washed with water
7. 7
   기타dried

실험 절차

A 47% hydrobromic acid solution was added to the compound of Example B146 (82 mg), and the mixture was stirred under reflux for 19 hours. The mixture was concentrated under reduced pressure, water was added, and the resulting mixture was neutralized with sodium carbonate to precipitate crystals. The obtained crystals were collected by filtration, washed with water, and then dried to give the title compound (74 mg).

출처