반응 #684962

반응 방정식

ammonium formate

compound

1-(3-Methoxyphenyl)-2-nitro-1-ethanol

→

title compound

수율 72.6%

2-Amino-1-(3-methoxyphenyl)-1-ethanol

수율 72.6%

용매

tetrahydrofuran

methanol

반응 조건

후처리

1. 1
   기타The catalyst was removed by filtration
2. 2
   workup.ADDITIONthe filtrate was diluted with ether
3. 3
   기타precipitates
4. 4
   기타were removed by filtration
5. 5
   농축the obtained filtrate was concentrated

실험 절차

Palladium-carbon (10%, 0.64 g) and ammonium formate (4.8 g) were added to a mixed solution of the compound of Example B142 (3.0 g, 15 mmol) in tetrahydrofuran (43 ml) and methanol (43 ml), and this mixture was stirred at room temperature for 18 hours. The catalyst was removed by filtration, the filtrate was diluted with ether, precipitates were removed by filtration, and the obtained filtrate was concentrated to give the title compound (1.82 g). This compound was used in the following reaction without further purification.

출처