반응 #684952

반응 방정식

sodium hydrogencarbonate

Methanesulfonyl chloride

triethylamine

o-iodobenzyl alcohol

→

title compound

수율 100.7%

1-(Chloromethyl)-2-iodobenzene

수율 100.7%

용매

methylene chloride

반응 조건

후처리

1. 1
   추출the resulting mixture was extracted with methylene chloride
2. 2
   건조The methylene chloride layer was dried over anhydrous magnesium sulfate
3. 3
   농축concentrated under reduced pressure

실험 절차

Methanesulfonyl chloride (2.0 ml, 29 mmol) and triethylamine (3.6 ml, 26 mmol) were added to a solution of o-iodobenzyl alcohol (5.0 g, 21 mmol) in methylene chloride (50 ml) cooled to 0° C., and the mixture was stirred at that temperature for 19 hours. A 5% aqueous sodium hydrogencarbonate solution was added, and the resulting mixture was extracted with methylene chloride. The methylene chloride layer was dried over anhydrous magnesium sulfate and concentrated under reduced pressure to give the title compound (5.34 g).

출처