반응 #68459

반응 방정식

NH3

(6-(3-methylisothiazol-5-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methanamine

8-chloro-3-methoxy-1,5-naphthyridine

2-butanol

→

title compound

수율 80.0%

7-methoxy-N-((6-(3-methylisothiazol-5-yl)-[1,2,4]-triazolo[4,3-b]pyridazin-3-yl)methyl)-1,5-naphthyridin-4-amine

수율 80.0%

용매

MeOH

반응 조건

후처리

1. 1
   기타Purification by MPLC (DCM/MeOH+1% NH4OH: 100/0 to 90/10)

실험 절차

(6-(3-methylisothiazol-5-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methanamine (548 mg, 2225 μmol) and 8-chloro-3-methoxy-1,5-naphthyridine (576 mg, 2959 μmol) were charged in a microwave vial. 2-butanol (7 mL) was added and the reaction mixture was stirred at 120° C. under micro-waves irradiation for 8 h. 2M NH3 in MeOH was added. Purification by MPLC (DCM/MeOH+1% NH4OH: 100/0 to 90/10) afforded the title compound (720 mg, 80% yield). MS m/z=405.1 [M+H]+. Calc'd for C19H16N8OS: 404.46

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