반응 #68453

반응 방정식

1-(6-chloropyridazin-3-yl)hydrazine

1-hydroxy-7-aza-benzotriazole

EDC

2-(7-methoxyquinolin-4-yloxy)acetic acid

diisopropylethylamine

→

N′-(6-chloropyridazin-3-yl)-2-(7-methoxyquinolin-4-yloxy)acetohydrazide

용매

DMF

반응 조건

후처리

1. 1
   농축Concentrated
2. 2
   농축Concentrated
3. 3
   온도with cooling
4. 4
   기타was isolated by filtration
5. 5
   기타Used without further purification

실험 절차

A mixture of 1-(6-chloropyridazin-3-yl)hydrazine (0.372 g, 2.57 mmol), 1-hydroxy-7-aza-benzotriazole (0.350 g, 2.57 mmol), EDC (0.641 g, 3.34 mmol), 2-(7-methoxyquinolin-4-yloxy)acetic acid (0.600 g, 2.57 mmol) and diisopropylethylamine (1.34 ml, 7.72 mmol) in DMF (20 mL) was allowed to stir at 50° C. for 2 h. Concentrated. Reconstitued in MeCN (30 mL). Concentrated with cooling. Product crashed out of solution and was isolated by filtration. Used without further purification. (ESI, pos. ion) m/z: 234.1 (M+H).

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